Introduction to Molecular Biology and Genetics

Course Description

Basics of cell biology and genetics: Structure of cells and cell types; Basic biochemical processes in the signal transduction; Genes and the laws of inheritance: Genetic linkage, and genetic modifications of classical inheritance ratios, multiple alleles, epistasis Basis of molecular biology: DNA - the discovery of the structure and function of hereditary material; DNA replication in prokaryotes and eukaryotes; DNA transcription and its regulation; Translation, structure of proteins and post-translational modifications; Regulation of gene expression in prokaryotes and eukaryotes Genetic Engineering: natural vs. "unnatural" changing of genomes of organisms: the classic tools of modification of the genome (vectors, restriction endonucleases, DNA ligases); Vectors, plasmids and DNA libraries; DNA sequencing Biotechnology: white, red and green biotechnology; tools of genetic engineering: Agrobacterium tumefaciens and microparticle bombardment; recombinant vaccine, monoclonal antibodies, industrial enzymes; transgenic plants and animals

Learning Outcomes

  1. Understand cells and genetic consequence of their devide
  2. Understand basic principles of Inheritance
  3. Describe DNA structure, replication and information expression
  4. Comprehend the idea behing recombinant DNA technology and why it opens new possibilities in application
  5. Explain the technical possibilities and constrains of biotechnology
  6. Be able to compare traditional and modern appraches in gene and genome manipulation
  7. Limits and unintended effects of gene technology

Forms of Teaching

Lectures

Seminars and workshops

Week by Week Schedule

  1. Cell structure and function
  2. Basic chemical processes and cell communication
  3. Genes and principles of inheritance
  4. Gene interactions and gene modification
  5. DNA, structure and inheritance
  6. DNA replication
  7. DNA transcription, DNA translation
  8. Midterm exam
  9. Gene modification, Principles and tools for gene manipulation
  10. Vectors and DNA libraries, DNA sequencing
  11. White, red and green biotechology
  12. Genetic engineering tools
  13. Recombinant vaccine, monoclove antibodies and gene gun
  14. Transgenic plants and animals
  15. Final exam

Study Programmes

University undergraduate
Free Elective Courses (5. semester)
Free Elective Courses (5. semester)
University graduate
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Literature

(.), Introduction to genetic analysis, Griffiths,
(.), Biotechnology for Beginners, Renneberg,

For students

General

ID 183410
  Winter semester
5 ECTS
L1 English Level
L1 e-Learning
45 Lectures
0 Seminar
0 Exercises
0 Laboratory exercises
0 Project laboratory

Grading System

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Good
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